Priming as a Means of Increasing Spontaneous Verbal Language in Children with Autism Spectrum Disorder

ABSTRACT THE EFFECTS OF PRIMING ON SPONTANEOUS VERBAL LANGUAGE IN CHILDREN WITH AUTISM SPECTRUM DISORDERS by Michelle L. Ivey A multi-element design was used to investigate the effect of priming on spontaneous verbal communication in children with Autism Spectrum Disorders (ASD). Three children with ASD engaged in 20-minute thematic activity sessions (ACT) with the investigator. Prior to the ACTs, they met with another trained researcher for 10-minute presessions. Half of the presessions incorporated the conventions of priming with materials to be used in the upcoming ACT (i.e., related presessions; RP). During the other half of the presessions, participants were not primed for the upcoming ACT (i.e., unrelated presesessions; UP). The researcher conducted presessions so the investigator was blind to the condition. Procedural fidelity checks of the presessions, based on a checklist of the critical components of priming, revealed 100% adherence to procedures. Participants’ utterances during ACT were recorded, transcribed, and coded based on functionality. The dependent variables were spontaneous comments, requests, topic initiations, social information seeking, and total. Once the criterion of a 30% increase from the mean of the first 3 UP was achieved for three consecutive sessions, priming was withdrawn and then reinstated to demonstrate a functional relation. Additionally, Cohen\u27s d was calculated to determine effect size for the intervention. Reliability was assessed for transcription and coding. There were fewer than 10 word disagreements on any transcript, which did not affect coding. A line by line comparison of the coding across the dependent variables yielded an average reliability of 85%. Visual inspection of the data and statistical analysis revealed that two of the three participants reached criterion for spontaneous comments (Cohen\u27s d = .32 and .95), one reached criterion for total utterances (Cohen\u27s d = 2.99), the other achieved the goal during the reinstatement following the withdrawal (Cohen’s d = 1.00). None increased requesting. Topic initiation and social information seeking did not occur with sufficient frequency for meaningful analyses. Similar to most interventions with individuals with ASD, priming was effective for increasing spontaneous verbal comments for some but not all of the participants. Priming was highly effective for two of the participants. This ground-breaking study creates momentum for further investigation and examination of the variables that affect benefit

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Publisher Copyright: © 2021, The Author(s).Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 x 10(-8); KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 x 10(-10); HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA). Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease.Peer reviewe